HIV-1 inhibitor-79

Description

HIV-1 inhibitor-79 Compound 3k is an HIV inhibitor that exhibits significant inhibitory activity against HIV-1 and its common mutant strains with IC50 values of 1.9, 1.9, 8.7, and 11 nM against HIV-1, K103, L100I, and E138K, respectively , and has low cytotoxicity and a high selectivity index CC50 = 21.95 ?M, SI = 11478 . Additionally, HIV-1 inhibitor-79 also shows antiviral activity against HIV-2, with an EC50 value of 6.14 ?M, and significantly inhibits the activity of HIV-1 reverse transcriptase IC50 = 25 nM .