

HY-159091 · 50 mg
MedChemExpress · Cat: HY-159091
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medchemexpress.com/hiv-1-integrase-inhibitor-12.htmlDescription
HIV-1 integrase inhibitor 12 Compound 17 is an inhibitor for HIV-1 integrase with an IC50 of 1.4 nM. HIV-1 integrase inhibitor 12 inhibits the HIV-1 WT and HIV-1 T125A, with IC50 of 7.4 and 120 nM, respectively. HIV-1 integrase inhibitor 12 exhibits metabolic stability and Caco-2 permeability, and good pharmacokinetic characteristics with good bioavailability 64 % and low clearance 0.16 L/hr/kg in rats.







