GENERAL CATALOGUE
HJM-561
HY-156698 · 5 mg
MedChemExpress · Cat: HY-156698
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medchemexpress.com/hjm-561.htmlCatalog No: HY-156698
CAS No: 2570251-68-0
Category: JAK STAT Signaling
Pack Size: 5 mg
Brand: MedChemExpress
Description
HJM-561 is a selective and effective orally active EGFR PROTAC degrader. HJM-561 is able to overcome the triple EGFR mutations that are resistant to Osimertinib HY-15772 . HJM-561 exhibits potent degradation of EGFR Del19/T790M/C797S DC50: 9.2 nM and L858R/T790M/C797S DC50: 5.8 nM , and has anti-tumor activity pink: EGFR ligand HY-12857 ; blue: CRBN ligand HY-A0003 ; black: linker .