GENERAL CATALOGUE
HL001
HY-124072 · 5 mg
MedChemExpress · Cat: HY-124072
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Catalog No: HY-124072
CAS No: 1186371-31-2
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
HL001 is an orally active small molecule inhibitor of Cyclophilin A CypA and a receptor antagonist of Lysophosphatidic acid 1 LPA1 . HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating G3BP1, inducing reactive oxygen species and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis.
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