GENERAL CATALOGUE
HLB-0532259
HY-168439 · 5 mg
MedChemExpress · Cat: HY-168439
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medchemexpress.com/hlb-0532259.htmlCatalog No: HY-168439
CAS No: 2566733-45-5
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
HLB-0532259 is a PROTAC degrader for Aurora-A and N-Myc. HLB-0532259 degrades Aurora-Ain a non-MYCN amplified MCF-7 with a DC50 of 20.2 nM, degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM. HLB-0532259 exhibits antitumor efficacy in mouse models. Pink: ligand for target protein HY-168440 ; Black: linker HY-W007957 ; Blue: ligand for E3 ligase Cereblon HY-41547
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