GENERAL CATALOGUE
HLDA-212
HY-173499 · 50 mg
MedChemExpress · Cat: HY-173499
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medchemexpress.com/hlda-212.htmlCatalog No: HY-173499
CAS No: 3077339-88-6
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
HLDA-212 Compound 43 is a bifunctional small molecule targeting HaloTag-tagged protein Target Protein, TP and Aurora kinase A/B AURKA/B, Effector Protein, EP . HLDA-212 binds to TP and EP to form a stable ternary complex TP:RIPTAC:EP , inhibiting the cell-survival function of EP and inducing apoptosis in TP-expressing cancer cells. HLDA-212 shows antiproliferative activity GI50 of 0.011 ?M in 293HFL cells. HLDA-212 is promising for research of cancers with high TP expression such as prostate cancer and hematological malignancies .
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