hMAO-B-IN-9

Description

hMAO-B-IN-9 Compound 25c is a non-competitive inhibitor for monoamine oxidase B MAO-B with an IC50 of 1.58 AAasAasAAmuM hMAO-B . hMAO-B-IN-9 forms complex with iron ions as a chelator, and inhibits Erastin HY-15763 -induced ferroptosis. hMAO-B-IN-9 exhibits antioxidant activity by downregulating the level of reactive oxygen species ROS . hMAO-B-IN-9 improves cognitive function in mice, without significant toxicity 30 mg/kg . hMAO-B-IN-9 is blood-brain barrier permeable, according to the in silico prediction.