HMGB1-IN-2

Description

HMGB1-IN-2 compound 15 is an inhibitor of highly conserved nuclear protein HMGB1 , showing NO inhibitory effect with IC50 value of 20.2 ?M in RAW264.7 cells. HMGB1-IN-2 30 ?M decreases the level of IL-1 ?, TNF-?, caspase-1 p20, inhibits the phosphorylation of NF-?B p65, exhibits anti-apoptotic activity. HMGB1-IN-2 15 mg/kg; ip relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC50s of 77.0 ?M, and 82.0 ?M, respectively.