GENERAL CATALOGUE
HOIPIN-8
HY-122882 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-122882
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medchemexpress.com/hoipin-8.htmlCatalog No: HY-122882
CAS No: 2519537-70-1
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex LUBAC with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-?-mediated NF-?B activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC.
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