GENERAL CATALOGUE
HQ461
HY-144981 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-144981
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Manufacturer product page
medchemexpress.com/hq461.htmlCatalog No: HY-144981
CAS No: 1226443-41-9
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death.
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