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Hsp90-Cdc37-IN-4
GENERAL CATALOGUE

Hsp90-Cdc37-IN-4

HY-174347 · 50 mg

MedChemExpress · Cat: HY-174347

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Catalog No: HY-174347
CAS No: 2758818-41-4
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

Hsp90-Cdc37-IN-4, a Celastrol HY-13067 derivative, inhibits the Hsp90-Cdc37 protein-protein interaction PPI . Hsp90-Cdc37-IN-4 selectively inhibits casein kinase 2 CK2 , reducing phosphorylation of its substrate Cdc37 at Serine 13. Hsp90-Cdc37-IN-4 induces G0/G1 cell cycle arrest and triggers apoptosis via the mitochondrial pathway. Hsp90-Cdc37-IN-4 demonstrates potent anti-breast cancer activity.

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