HSP90-IN-11

Description

HSP90-IN-11 Compound 12c is a potent inhibitor of HSP90. HSP90-IN-11 displays potent HSP90? inhibition comparable to AUY-922 Luminespib . HSP90-IN-11 shows significant antiproliferative activity in CRC and NSCLC cells in a double digit nM range. HSP90-IN-11 leads to rapid degradation of client proteins EGFR and Akt in NSCLC cells. HSP90-IN-11 induces significant accumulation of a sub-G1 phase population.