Hsp90-IN-42

Description

Hsp90-IN-42 Compound 13l is a potent heat shock protein 90 Hsp90 inhibitor IC50=15.65 nM . Hsp90-IN-42 reduces the stability of the epidermal growth factor receptor EGFR , suppressing the activation of the EGFR-Akt signaling pathway, inducing G0/G1 phase arrest in colorectal cancer cells such as HT-29 cells , and slightly triggering apoptosis. Hsp90-IN-42 also inhibits cell proliferation and migration by down-regulating the expression of CDK12, CDK13, and Bcl-2 proteins, and up-regulating the expression of Bax protein. Hsp90-IN-42 is promising for research of colorectal cancer.