HSV-1/HSV-2-IN-3

Description

HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus HSV helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC50 of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC50 of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets IC50 ? 2.9 AAasAasAAmuM for hCA II and 35 AAasAasAAmuM for hCA I. HSV-1/HSV-2-IN-3 can be studied in anti-HSV research.