GENERAL CATALOGUE
HTH-02-006
HY-156397 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-156397
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Manufacturer product page
medchemexpress.com/hth-02-006.htmlCatalog No: HY-156397
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
HTH-02-006 is a NUAK2 inhibitor, with an IC50 value of 126 nM. HTH-02-006 inhibits NUAK2-mediated signaling by reducing phosphorylation of its substrate MYPT1 at S445 and downstream MLC. HTH-02-006 shows growth inhibitory efficacy in YAP-high cancer cells HuCCT-1, SNU475 . HTH-02-006 significantly suppresses YAP-induced hepatomegaly reduced liver/body weight ratio in TetO-YAP S127A transgenic mice and demonstrates significant anti-tumor efficacy in mice bearing HMVP2 prostate cancer allografts. HTH-02-006 can be used for the study of liver cancer and prostate cancer.
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