HTS05585

Description

HTS05585 Compound Hit-1 is a selective macrophage migration inhibitory factor MIF inhibitor with a Kd value of 0.29 ?M measured by microscale thermophoresis MST and 0.32AAasAasAA+/-0.01 ?M verified by isothermal titration calorimetry ITC . HTS05585 inhibits the release of pro-inflammatory factors TNF-?, IL-6, IL-1? from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis.