Human Adrenocortical HAC50 Cells

Description

Clonal cell line isolated from NCIH295R. The HAC50 cells increase aldosterone production in response to treatment with angiotensin II and high extracellular potassium levels. These cells respond to activation cAMP signaling pathway agonists, forskolin and dibutyryl cAMP, with a time-dependent increase in cortisol and dehydroepiandrosterone production. In summary, the HAC50 cell line is capable of responding to the three main adrenocortical physiologic regulators.