Human PIK3R1 CRISPR Knockout TeloHAEC Cell Line - AP209

Description

This cell line has been genetically modified using CRISPR/Cas9 technology to knock out the PIK3R1 gene, which encodes the regulatory subunit of phosphoinositide 3-kinase PI3K . The absence of PIK3R1 disrupts PI3K signaling, providing a valuable model for studying the role of PI3K in endothelial function, vascular biology, and related signaling pathways. Applications of this stable cell line include research in cardiovascular diseases, angiogenesis, and cancer biology, offering insights into the development of targeted therapies and the exploration of PI3K-related cellular mechanisms.