Human STAT2 Stable Knockout HeLa Cell Line

Description

The Human STAT2 Stable Knockout HeLa Cell Line T3983 lacks the STAT2 gene, another crucial component of the JAK-STAT signaling pathway, pivotal for Type I interferon responses. STAT2 plays a significant role in forming the ISGF3 complex, which translocates to the nucleus to initiate the transcription of ISGs. This knockout model facilitates the study of STAT2s specific functions in interferon signaling, its interaction with other STAT proteins, and the broader implications of STAT2-mediated gene regulation in antiviral defense and immune modulation. Complete list of cell lines from this panel: Cat. T3980 - Human IFNAR1 Stable Knockout HeLa Cell Line Cat. T3981 - Human IFNAR2 Stable Knockout HeLa Cell Line Cat. T3982 - Human STAT1 Stable Knockout HeLa Cell Line Cat. T3983 - Human STAT2 Stable Knockout HeLa Cell Line