GENERAL CATALOGUE
Hydrastine
HY-B0927 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-B0927
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Catalog No: HY-B0927
CAS No: 118-08-1
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Hydrastine - -?-Hydrastine; 1R,9S -?-Hydrastine is a selective competitive inhibitor of tyrosine hydroxylase TH , inhibiting dopamine biosynthesis IC50=20.7 ?M, PC12 cells . Hydrastine also inhibits the organic cation transporter OCT1 IC50=6.6 ?M . Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinsons disease-related dopaminergic neuronal damage.
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