GENERAL CATALOGUE
I-CBP112 hydrochloride
HY-19541A · 1 mg
MedChemExpress · Cat: HY-19541A
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Manufacturer product page
medchemexpress.com/i-cbp112-hydrochloride.htmlCatalog No: HY-19541A
CAS No: 2147701-33-3
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
I-CBP112 hydrochloride is a selective inhibitor of CBP/P300 that directly binds their bromodomains Kds = 142 and 625 nM, respectively . I-CBP112 significantly reduces the leukemia-initiating potential of MLL-AF9 + acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. I-CBP112 increases the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
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