ICMT-IN-35

Description

ICMT-IN-35 compound 10n is a FTPA-triazole compound and ICMT inhibitor IC50=0.8 ?M . ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity IC50=0.8 ?M against metastatic pancreatic cancer cell lines.