GENERAL CATALOGUE
Icotrokinra
HY-P10587 · 1 mg
MedChemExpress · Cat: HY-P10587
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Catalog No: HY-P10587
CAS No: 2763602-16-8
Category: Immunology Inflammation
Pack Size: 1 mg
Brand: MedChemExpress
Description
Icotrokinra JNJ-77242113 is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells IC50=5.6 pM and inhibits IL-23-induced interferon IFN-? production in NK cells with an IC50 of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease.
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