GENERAL CATALOGUE
ID11916
HY-173640 · 50 mg
MedChemExpress · Cat: HY-173640
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medchemexpress.com/id11916.html
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Catalog No: HY-173640
CAS No: 2785317-21-5
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
ID11916 is an orally active androgen receptor AR antagonist and a phosphodiesterase 5 PDE5 inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3.
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