GENERAL CATALOGUE
Idebenone
HY-N0303 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-N0303
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Catalog No: HY-N0303
CAS No: 58186-27-9
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimers disease, Huntingtons disease. Idebenone oxidised form has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates IC50=16.65 ?M . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells. Idebenone quickly crosses the blood-brain barrier.
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