IDH1/2-IN-1

Description

IDH1/2-IN-1 Compound 6b serves as a dual inhibitor of IDH1 R132H /IDH2 R140Q with IC50 values of 0.22 ?M and 1.6 ?M, respectively. IDH1/2-IN-1 effectively inhibits tumor growth by suppressing tumor cell proliferation and enhancing host defense through the activation of antioxidant enzymes. Additionally, IDH1/2-IN-1 reduces inflammation and promotes apoptosis, demonstrating robust antitumor activity. IDH1/2-IN-1 holds potential for research in leukemia.