IDOi-Pt(IV) prodrug-1

Description

IDOi-Pt IV prodrug-1 Compound 10 is an IDOi-Pt IV prodrug. IDOi-Pt IV prodrug-1 inhibits IDO expression. IDOi-Pt IV prodrug-1 induces apoptosis, decreases the mitochondrial membrane potential, inhibits tumor cell migration and invasion. IDOi-Pt IV prodrug-1 induces reactive oxygen species-mediated endoplasmic reticulum stress and secretion of damage-associated molecular patterns DAMPs , thereby presenting immunogenic cell death ICD effects. IDOi-Pt IV prodrug-1 has high-efficiency and low-toxicity antitumor effects compared to Cisplatin HY-17394 .