IGN523

Description

IGN523 is an anti-CD98 antibody hCD98, KD = 0.55 nM . IGN523 induces antibody-dependent cell-mediated cytotoxicity ADCC activity, lysosomal membrane permeabilization, and inhibition of essential amino acid transport, ultimately leading to caspase-3 and caspase-7-mediated apoptosis of tumor cells. IGN523 inhibits tumor growth in multiple tumor xenograft models. IGN523 is useful in the research of non-small cell lung cancer NSCLC , acute myeloid leukemia AML , and other cancers..