IL-12B/p40/NKSF2, His, Human

Description

Interleukin IL 12B, which encodes the p40 subunit common to IL12 and IL23, as one of the genes for which expression in fibroblastlike synoviocytes from patients with rheumatoid arthritis RAFLS is induced by DcR3.Decoy receptor 3 DcR3 competitively binds to three ligands, Fas ligand, lymphotoxinrelated inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factorlike ligand 1A TL1A , to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand.