Integrin beta 3 Rabbit Polyclonal Antibody

Description

EnkiLife offers the Integrin beta 3 Rabbit Polyclonal Antibody. This antibody reacts with Human species and is suitable for WB,IHC,ELISA application. Alternative Names of Immunogen: ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100,ELISA 1:5000-1:20000 Background: Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). Research Area: Cardiovascular