Ilicicolin F

Description

Ilicicolin F is a fungal metabolite that has been found in Fusarium and has diverse biological activities. It inhibits T. vivax alternative oxidase and the E. coli ubiquinol oxidase cytochrome bo IC50s=0.43 and 0.37 ?M, respectively but not the E. coli ubiquinol oxidase cytochrome bd IC50=85 ?M .2 Ilicicolin F is active against the fungi A. fumigatus and C. albicans MICs=1.66-3.33 and 6.66-13.33 ?g/mL, respectively . It is cytotoxic to HeLa cells with an EC50 value of 0.003 ?g/mL.