GENERAL CATALOGUE
ILK-IN-2
HY-18676B · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-18676B
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Catalog No: HY-18676B
CAS No: 1333146-24-9
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ILK-IN-2 OSU-T315 analog is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 ?M. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia CLL and extending the lifespan in TCL1 mouse models.
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