GENERAL CATALOGUE
IMC-EB10
HY-P991641 · 1 mg
MedChemExpress · Cat: HY-P991641
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medchemexpress.com/imc-eb10.html
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Catalog No: HY-P991641
Category: JAK STAT Signaling
Pack Size: 1 mg
Brand: MedChemExpress
Description
IMC-EB10 LY3012218 is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to FLT3 with high affinity Kd = 158 pM and blocks the binding of FLT3 ligand to FLT3 IC50 ? 10 nM , thereby inhibiting MAPK, STAT5, and PI3K/Akt signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate HY-14519 and inhibit leukemias expressing wild-type or ITD-mutated FLT3 receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia ALL cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research.
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