Immortalized Human Gastric Cells (KMU-CS12)

Description

The Immortalized Human Gastric Cells KMU-CS12 were derived from isolated gastric cell clones developed from gastric biopsy samples and were spontaneously immortalized in subsequent cultures. The growth of this cell line was found to be significantly faster than its parental gastric cells. This cell line shows cancer cell phenotypes with tumorigenic ability as tested in immunodeficient nude mice. Another unique characteristic of the Immortalized Human Gastric Cells KMU-CS12 is the high expression of homeobox genes: HOXA4, HOXA5, HOXA7, HOXA9, and HOXA13. This makes the cell line useful in the construction of HOXA genes knockdown models as well as in research focusing on the chromosomal mutations in HOXA gene family. The Immortalized Human Gastric Cells KMU-CS12 is also valuable in cancer research particularly in the etiology and studying new therapeutic strategy for gastric cancer.