Immortalized Mouse Articular Chondrocytes (iMAC)

Description

The Immortalized Mouse Articular Chondrocytes are hygromycin-resistant, non-tumorigenic reversibly immortalized cells that retains both morphological and chondrogenic features. Specifically, it expresses chondrocyte markers such as Col 2a1 type II collagen , aggrecan, Sox9, TNFalpha, IL-6, and COX2. In the presence of BMP2 abm Cat. No. Z100085 , the cells are able to produce mature chondroid matrix. These cells are unique, as the immortalization process may be reversed by infection with Cre-recombinase expressing adenoviruses abm Cat. No. 000018A , thus reverting immortal cells back into primary cells. These cells are a valuable tool in chondrogenesis molecular mechanism, and cartilage tissue regeneration studies to identify biofactors promoting proliferation and differentiation of chondrogenic progenitors.