Immortalized Mouse Hepatic Sinusoidal Endothelial Cells - SV40

Description

Hepatic sinusoidal endothelial cells HSECs are an unique sub-population of liver cells that line the hepatic sinusoids. Their role involves clearing waste products from the blood, regulating pericyte contractility and innate immune functions. The Immortalized Mouse Hepatic Sinusoidal Endothelial Cells - SV40 is derived from C57BL/6 mouse HSECs that have maintained endothelial characteristics and HSEC-specific features such as vWF and caveolin-1. These cells also migrate in response to angiogenici growth factors, form vascular tube-like structures, endycytose acetylated low-density lipoprotein AcLDL and secrete proteins involved in matrix remodelling. In addition, these cells are easily transduced by retrovirus. The Immortalized Mouse Hepatic Sinusoidal Endothelial Cells- SV40 is therefore suitable for studying liver endothelial cell biology, including motility and angiogenesis.