Immortalized Mouse Pituitary Progenitor Cells (alphaT1-1)

Description

Immortalized Mouse Pituitary Progenitor Cells alphaT1-1 represent a progenitor to the gonadotrope and/or thyrotrope lineages generated by directing expression of the oncogene SV40 T antigen using a gonadotrope-specific region of the human glycoprotein hormone alpha-subunit gene in transgenic mice. Immortalized Mouse Pituitary Progenitor Cells alphaT1-1 provide a novel model system in which the molecular mechanism of pituitary cellular differentiation can be dissected. Characterization conducted by pituitary cell differentiation and pituitary transcription factor expression.