Immortalized Mouse TMJ Disc Fibroblast-Like Cells

Description

The temporomandibular joint TMJ is the jaw joint that hinges to allows complex movements related to eating and swallowing. TMJ disc tissue permits mandibular movement and its degeneration has been linked to many clinical pathologies related to joint function, including crepitus, arthritis and headdaches. TMJ disc tissue comprises of a complex matrix of cells with regional difference in morphology, including chondrocyte -like cells and fibroblast-like cells. This organization of cells allow for the disspation of forces acting on the jaw joint. Immortalized Mouse TMJ Disc Fibroblast-Like Cells were derived from fibroblast-like cells from a 12-week-old female mouse. These cells are designed to be suitable for cell-type specific studies on the physiology and progression of TMJ disc disorders. Characterization was conducted by Western blot, qRT-PCR, and immunofluorescence. These cells demonstrate trilineage differentiation potential, with the ability to undergo adipocytic, osteoblastic, and chondrocytic differentiation under defined in vitro conditions Park, Y et al., 2015 .