Immortalized Rat Arachnoid Cells - SV40/hTERT

Description

The arachnoid cells are important in the maintenance of apical-basal polarity and the formation of tight junctions at the cerebrospinal fluid-blood barrier CSF-blood barrier . The Immortalized Rat Arachnoid cells-SV40/hTERT derived from primary rat arachnoid cells maintained the ability to form intact epithelial monolayer and displayed normal immunohistochemical and morphological phenotypes. As such, the cell line is useful in physiological studies in modeling arachnoid granulations and cerebrospinal fluid flow. In addition, this cell line is also useful in pathological conditions such as hydrocephalus, arachnoid cysts, or other disorders. It has the ability to form tight junctions as measured by TEER and radiochemical i.e. TEER value of 193 SEM ohm-cm2 is comparable to 206 SEM ohm-cm2 value of that of Caco-2 cells .