GENERAL CATALOGUE
IMPDH-IN-4
HY-161712 · 5 mg
MedChemExpress · Cat: HY-161712
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medchemexpress.com/nampt-in-12.htmlCatalog No: HY-161712
CAS No: 2427862-70-0
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
IMPDH-IN-4 is a derivative of N-pyridinylthiophene carboxamid that exhibits activity against peripheral nerve sheath carcinoma cells. IMPDH-IN-4 is metabolized by NAMPT and NMNAT1 to an adenine dinucleotide AD derivative, which is an NAD analog and can inhibit inosine monophosphate dehydrogenase IMPDH , leading to the accumulation of inosine monophosphate IMP in cells. IMPDH-IN-4 has good blood-brain barrier permeability and can be used in the study of central and peripheral nervous system cancers.
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