GENERAL CATALOGUE
IMT1
HY-134539 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-134539
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Catalog No: HY-134539
CAS No: 2304621-31-4
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase POLRMT inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
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