INF200

Description

INF200 compound 5 is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet HFD -induced metaflammation?and shows anti-inflammatory activity to 10 ?M decreases IL-1? release in human macrophages. INF200 improves glucose and lipid profiles?and attenuates systemic inflammation and biomarkers of cardiac dysfunction particularly BNP . INF200 also improves myocardial damage-dependent ischemia/reperfusion injury IRI in hemodynamic evaluation.