Inosine-5'-diphosphate-15N4 dilithium

Description

Inosine-5-diphosphate-15N4 dilithium IDP-15N4 dilithium is 15N labeled Inosine-5-diphosphate dilithium. Inosine-5-diphosphate IDP is a decoy substrate of NM23-H2. Inosine-5-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 KD: 5.0 ?M . Inosine-5-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of ?-irradiation. Inosine-5-diphosphate can be used for cancers like Burkitts lymphoma and cardiovascular diseases research.