Inosine-5'-diphosphate disodium

Description

Inosine-5-diphosphate disodium IDP disodium is a decoy substrate of NM23-H2. Inosine-5-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 KD: 5.0 ?M . Inosine-5-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of ?-irradiation. Inosine-5-diphosphate disodium can be used for cancers like Burkitts lymphoma and cardiovascular diseases research.