GENERAL CATALOGUE
Ipatasertib
HY-15186 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-15186
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medchemexpress.com/GDC-0068.html
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Catalog No: HY-15186
CAS No: 1001264-89-6
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Ipatasertib GDC-0068 is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC50 values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-?B through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.
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