IPC-366 Cells

Description

IPC-366 Cells are derived from a triple negative ER-, PR-, HER-2- canine primary inflammatory mammary cancer IMC sample that was obtained after the euthanasia of the clinically diagnosed female dog. The morphology of these cells when adhered is epithelial-like and they are positive for general epithelial markers pancytokeratin, AE1/AE3 as well as the basal marker CK14. Cells also over express E-cadherin and COX-2 and have a high rate of proliferation, but lack p63 and smooth muscle actin. IPC-366 Cells share several characteristics to human derived IMC line, SUM149, including its triple negative nature, and epithelial-like morphology. Due to these similarities, IPC-366 Cells may be useful as a model for study of inflammatory breast cancer.