GENERAL CATALOGUE
IPG7236
HY-153670 · 5 mg
MedChemExpress · Cat: HY-153670
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Catalog No: HY-153670
CAS No: 2756350-91-9
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
IPG7236 is a selective and orally active CC chemokine receptor 8 CCR8 antagonist with an IC50 of 24 nM in a Tango assay. IPG7236 effectively inhibits the downstream signaling of CCR8 induced by CCL1 IC50 = 8.44 nM , CCL1-induced downstream signaling in the CCR8-overexpressing cells IC50 = 24.3 nM , and CCL1-induced CCR8+ Treg cellsAAasAasAa migration IC50 = 33.8 nM .IPG7236 demonstrates an anti-cancer effect via up-regulating Treg and down-regulating cytotoxic T CD8+ T cells. IPG7236 can used for the study of breast cancer.
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