GENERAL CATALOGUE
IRE1? kinase-IN-1
HY-136735 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-136735
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Catalog No: HY-136735
CAS No: 2328097-41-0
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
IRE1? kinase-IN-1 is a highly selective IRE1? ERN1 inhibitor, with an IC50 of 77 nM. IRE1? kinase-IN-1 displays 100-fold selectivity for IRE1? over the IRE1? isoform. IRE1? kinase-IN-1 inhibits ER stress-induced IRE1? oligomerization and autophosphorylation, and also inhibits IRE1? RNase activity IC50=80 nM .
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