IRE1α/β Rabbit Polyclonal Antibody

Description

EnkiLife offers the IRE1α/β Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: ERN2; IRE2; Serine/threonine-protein kinase/endoribonuclease IRE2; Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; hIRE2p; Ire1-beta; IRE1b. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:100-1:300,ICC/IF 1:200-1:1000,ELISA 1:5000-1:20000 Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. PTM:Autophosphorylated. similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. similarity:Contains 1 KEN domain. similarity:Contains 1 protein kinase domain.