IRF8 Rabbit Monoclonal Antibody

Description

EnkiLife offers the IRF8 Rabbit Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,IHC,IP application. Alternative Names of Immunogen: ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:1000,IHC 1:50-1:100,IP 1:20-1:50 Background: Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes . Research Area: Epigenetics and Nuclear Signaling